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Heart failure and cardiomyopathy
Serum intact parathyroid hormone levels predict hospitalisation for heart failure
  1. T Sugimoto1,
  2. T Tanigawa1,
  3. K Onishi2,
  4. N Fujimoto3,
  5. A Matsuda1,
  6. S Nakamori1,
  7. K Matsuoka1,
  8. T Nakamura1,
  9. T Koji1,
  10. M Ito3
  1. 1
    Cardiology, Matsusaka Chuo General Hospital, Matsusaka, Japan
  2. 2
    Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan
  3. 3
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
  1. Dr K Onishi, Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, 2–174 Edobashi, Tsu 514–8507, Japan; katsu{at}


Objective: To assess whether circulating levels of intact parathyroid hormone (intact PTH) in outpatients predict hospitalisation for heart failure (HF).

Methods: Eighty-eight consecutive outpatients with HF were enrolled in the study. The independent association between intact PTH and hospitalisation for HF was assessed using Cox regression analysis.

Results: Mean (SD) serum intact PTH levels significantly increased as New York Heart Association classes increased (I: 40 (21), II: 55 (24), III: 76 (46), IV: 131 (45) pg/ml). The receiver operating characteristic (ROC) curves showed intact PTH levels ⩾47 pg/ml to be the optimal cut-off points for hospitalisation for HF, with sensitivity 87%, specificity 71% and area under the ROC curve 0.82 (95% CI 0.72 to 0.91). After adjustment for variables accepted to be predictors for hospitalisation due to HF (age, gender, hypertension, diabetes mellitus, atrial fibrillation, ischaemic heart disease, left ventricular ejection fraction, B-type natriuretic peptide, estimated glomerular filtration rate and cardiac drugs), intact PTH levels ⩾47 pg/ml were associated with a hazard ratio of 7.13 for hospitalisation for HF (95% CI 1.79 to 28.4).

Conclusion: Serum intact PTH levels obtained in outpatients with HF were shown to be an independent predictor of hospitalisation for HF.

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  • Competing interests: None.

  • Ethics approval: Ethics committee approval obtained.