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The authors’ reply:
  1. R K Riezebos,
  2. G J Laarman
  1. Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
  1. Dr R K Riezebos, Onze Lieve Vrouwe Gasthuis, Department of Cardiology, PO Box 95500, 1090HM, Amsterdam, The Netherlands; r.k.riezebos{at}

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In our study, we reported an increased rate of myocardial infarction (MI) in high-risk patients with non-refractory non-ST-segment elevation acute coronary syndromes (NSTE-ACS) treated with immediate percutaneous coronary intervention (PCI) as compared with a 24 h deferred PCI.1

The use of biomarkers for detection of MI is generally accepted and in our view legitimate as study end point.2 Also, employing higher cut-off …

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