A 66-year-old woman, with a history of mediastinal radiotherapy for Hodgkin's lymphoma, presented with exertional breathlessness and was diagnosed with severe aortic valve regurgitation on echocardiography (panel A). The regurgitation was likely due to radiotherapy-induced retraction of her aortic valve leaflets without valve-ring dilatation. She had previously sustained radiotherapy-induced ostial occlusions of her left anterior descending and right coronary arteries, but …