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AMIS Plus: Swiss registry of acute coronary syndrome
  1. Dragana Radovanovic1,
  2. Paul Erne2
  1. 1AMIS Plus Data Center, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
  2. 2Department of Cardiology, Luzerner Kantonsspital, Lucerne, Switzerland
  1. Correspondence to Professor Paul Erne, Department of Cardiology, Luzerner Kantonsspital, CH-6000 Lucerne 16, Switzerland; paul.erne{at}


AIMS of AMIS Plus To learn from each other, to understand the transfer, use and practicability of knowledge gained from randomised trials and to generate input for subsequent prospective and randomised studies. Furthermore, to determine how adherence to guideline-based treatments in the ‘real world’ works.

Funding AMIS Plus is an industry-sponsored project but the supporting institutions do not play any part in the design of the registry, data collection, analysis or interpretation.

Quality-of-care interventions AMIS Plus data enable doctors to identify deficits in medical care, implement the necessary changes in diagnostics and therapeutic procedures and document their impact on clinical outcome in patients with acute coronary syndrome (ACS).

Setting From 106 hospitals treating ACS in Switzerland, 76 hospitals temporarily or continuously enrolled patients in AMIS Plus. Years: 1997–

Population Patients are included on the basis of their final diagnosis. Current number of cases: 33 040.

Start points ST elevation myocardial infarction, non-ST elevation myocardial infarction and since 2000, unstable angina.

Baseline data 230 variables are collected including demographics, medical history, cardiovascular risk factors, acute symptoms, time of symptom onset, first medical contact, time of admission and start of thrombolysis or balloon, out of hospital management, clinical presentation, early in-hospital management, reperfusion treatment, hospital course, diagnostic tests used or planned, hospital length of stay, discharge medication, destination and at 1 year, outcome, rehospitalisation, intervention, working time and quality of daily life.

Data capture Data are provided through an internet- or paper-based questionnaire completed by the treating doctor or a trained study nurse.

Data quality The data are centralised at the AMIS Plus Data Center, checked for plausibility and consistency and crosschecked when queries arise. Incomplete questionnaires are returned to the enrolment centres for completion. One-third of the variables are obligatory.

End point and linkages to other data In-hospital outcome, 3-months and 1-year follow-up outcome. No linkages exist at present.

Access to data Available for research with the approval of the AMIS Plus Steering Committee. Participating hospitals use the data for benchmarking and their own quality control.

  • Acute coronary syndrome
  • registry
  • outcome

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  • Funding Sources 2009 Main sponsors Astra-Zeneca, Bayer-Schering, Biotronik, Daiichi-Sankyo/Lilly, Invatec, A. Menarini, Medtronic, St. Jude Medical, all in Switzerland. Donators: Abbott, Biosensors, Bristol-Myers Squibb, GlaxoSmithKline, Johnson & Johnson, Merck Sharp & Dohme-Chibret, Essex, Novartis, Pfizer, Sanofi-Aventis, Servier, SPSS and Takeda, all in Switzerland.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Over-Regional Ethics Committee for Clinical Studies, the Swiss Board for Data Security and all cantonal Ethic Commissions.

  • Provenance and peer review Commissioned; externally peer reviewed.