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Impact of restrictive physiology on intrinsic diastolic right ventricular function and lusitropy in children and adolescents after repair of tetralogy of Fallot
  1. Christian Apitz1,
  2. Heiner Latus1,
  3. Wolfhard Binder1,
  4. Anselm Uebing2,
  5. Achim Seeger3,
  6. Christiane Bretschneider3,
  7. Ludger Sieverding1,
  8. Michael Hofbeck1
  1. 1Division of Pediatric Cardiology, University Children's Hospital, Tuebingen, Germany
  2. 2Division of Pediatric Cardiology, University Children's Hospital, Kiel, Germany
  3. 3Department of Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany
  1. Correspondence to Dr Christian Apitz, Division of Pediatric Cardiology, University Children's Hospital, Feulgenstr. 12, D-35392 Giessen, Germany; capitz{at}


Background Restrictive right ventricular (RV) physiology is a phenomenon considered potentially beneficial when detected in children and adolescents with repaired tetralogy of Fallot (ToF). It is typically characterised by antegrade flow in the pulmonary artery in late diastole at the time of atrial contraction. However, little is known about the impact of restrictive physiology on intrinsic diastolic RV function or lusitropy.

Methods Diastolic function was prospectively assessed at baseline level and during dobutamine infusion using the pressure–volume conductance system. End diastolic forward flow in the pulmonary artery was measured by MRI.

Results Twenty-five patients aged 17.9±7.5 years were studied. Although the end diastolic RV pressure, the time constant of isovolumic RV relaxation (τ) and dP/dtmin were similar between both groups, the slope of the end diastolic pressure–volume relationship (Eed) was significantly higher in the restrictive group indicating increased diastolic stiffness in these patients (0.14±0.05 vs 0.06±0.01, p=0.03). Dobutamine stress, however, led to an increase in Eed in the entire ToF cohort indicating an abnormal diastolic response to catecholamines in these patients.

Conclusions Diastolic RV stiffness of repaired ToF patients with restrictive physiology is increased. The lusitropic response of the RV to β adrenergic agents is abnormal after ToF repair regardless of whether restrictive physiology is present or not. This has potential implications, particularly for postoperative drug management.

  • Diastolic dysfunction
  • Fallots tetralogy
  • paediatric cardiology
  • paediatric cardiac function

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  • Funding This study was financially supported by the Fördergemeinschaft Deutsche Kinderherzzentren, Bonn, Germany.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the ethics committee of the medical faculty at the University of Tübingen.

  • Provenance and peer review Not commissioned; externally peer reviewed.