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Interventional cardiology
Transcatheter valve implantation for patients with aortic stenosis
  1. Alec Vahanian,
  2. Dominique Himbert,
  3. Eric Brochet
  1. Department of Cardiology, Hôpital Bichat, Paris, France
  1. Correspondence to Professor Alec Vahanian, Department of Cardiology, Hôpital Bichat, 46 rue Henri Huchard 75018, Paris, France; alec.vahanian{at}bch.aphp.f

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Aortic stenosis (AS), which is now the most frequent native valve disease in Europe, has a predominantly degenerative origin and is mostly seen in elderly patients. Valve replacement is the definitive therapy1; however, the risk of surgery is high in elderly patients with significant comorbidities.2 In addition, several registries show that as many as one third of patients with severe valve disease and severe symptoms are not being considered for surgery.3 Thus, there is a role for less invasive alternatives. Balloon aortic valvuloplasty (BAV) is now rarely used in isolation, mainly due to its limited long term efficacy.

Seven years after its introduction in clinical practice by Alain Cribier,4 transcatheter aortic valve implantation (TAVI) currently represents a dynamic field of research and development.

Two devices are commercially available for TAVI (figure 1). One device is the Edwards-Sapien valve, which consists of three bovine pericardial leaflets, mounted within a tubular, slotted, stainless steel, balloon expandable stent. It is currently available in 23 and 26 mm sizes, necessitating, respectively, 22F and 24F introducer sheaths for the transfemoral approach and 26F for the transapical approach. The other device is the Medtronic CoreValve which has three porcine pericardial leaflets (initially bovine) mounted in a self expanding nitinol frame. It is available in 26 and 29 mm sizes, which go through an 18F introducer for transfemoral or transaxillary use.

Figure 1

Commercially available prostheses. (A) Edwards Sapien Transcatheter Heart Valve and the third generation of RetroFlex catheter with the balloon and its distal nose cone. (B) Medtronic CoreValve System and the third generation 18F catheter.

The selection of candidates for TAVI and the performance of the procedure require the cooperation of a multidisciplinary team including cardiologists, surgeons, imaging specialists and anaesthetists, all with experience in the management of valve disease.5

This review will …

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  • Competing interests In compliance with EBAC/EACCME guidelines, all authors participating in Education in Heart have disclosed potential conflicts of interest that might cause a bias in the article. AV undertakes consulting for Edwards Lifesciences, and DH acts as a physician for Edwards Lifesciences.

  • Provenance and peer review Commissioned; not externally peer reviewed.

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