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The Authors' reply: We thank Dr Forge for these comments,1 but suspect that the findings and the purpose of our study have been over-interpreted.2 The relevance of clinical registries has been called into question. As the impact of both measured and unmeasured biases cannot be fully controlled, registries are imprecise tools for estimating the effect size of any treatment. This analysis does not seek to take precedence over randomised clinical trials. Rather, such analyses have utility in supporting existing randomised trial evidence and add to the ‘totality of data’ that informs clinical …
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Competing interests Dr Chew receives funding from Sanofi-Aventis Australia; Dr Eagle receives funding from Biosite, Bristol Myers Squibb, Cardiac Sciences, Blue Cross Blue Shield of Michigan, Hewlett Foundation, Mardigian Fund, Pfizer, Sanofi-Aventis, Varbedian fund, National Heart, Lung & Blood NIH; Drs Anderson, Avezum, Gulba, Gore, and Brieger and Ms Dedrick receive funding from Sanofi-Aventis. The GRACE registry was sponsored by Sanofi Aventis.
Provenance and peer review Commissioned; not externally peer reviewed.