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Myocardial energetics and redox in health and disease
010 Cardiomyocyte-specific overexpression of Nox4 attenuates adverse cardiac remodelling after myocardial infarction
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  1. M Zhang
  1. King's College London, BHF Centre of Excellence, The James Black Centre, London, UK

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Background

Reactive oxygen species (ROS) production is implicated in the development of cardiac remodelling after myocardial infarction (MI). NADPH oxidases are major sources of cardiovascular ROS, with cardiomyocytes expressing both Nox2 and Nox4 isoforms. We previously showed that Nox2 contributes significantly to the processes underlying adverse cardiac remodelling and contractile dysfunction post-MI, but the effect of Nox4 remains unclear. The aim of this study …

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