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Myocardial energetics and redox in health and disease
013 Regulation of gene transcription by hydrogen peroxide in cardiomyocytes
  1. K Lay
  1. National Heart and Lung Institute, Cardiovascular Science, Imperial College London, London SW7 2AZ, UK

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Reactive oxygen species (ROS) levels rise during ischaemia and reperfusion and may contribute to myocardial injury, remodelling and progression to heart failure. ROS (hydrogen peroxide; H2O2) activates both apoptotic and pro-survival signalling pathways, although at higher concentrations cardiomyocyte death invariably results. Here, …

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