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Myocardial energetics and redox in health and disease
016 Evidence for inward rectifier potassium channels in HL-1 cells
  1. D Goldoni
  1. Centre for Vision and Vascular Science, School of Medicine and Dentistry, Queens University Belfast, Belfast, UK

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Cardiac inward rectifier potassium current (IK1) plays a paramount role in repolarisation and stabilisation of the membrane potential in cardiomyocytes. Its downregulation contributes to arrhythmogenesis in heart failure and post-myocardial infarction. We have undertaken the molecular and functional characterisation of IK1 in the HL-1 cell line, which is derived from a …

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