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BSCR Autumn Meeting Abstracts, 2009
Myocardial energetics and redox in health and disease
024  Endothelial Nox4 NADPH oxidase enhances vasodilatation via hydrogen peroxide-induced hyperpolarisation and reduces blood pressure
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  1. M Wang
  1. King's College London BHF Centre of Excellence, The James Black Centre, London, UK

https://doi.org/10.1136/hrt.2009.191064l

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    Introduction

    NADPH oxidases (Noxs) are reactive oxygen species-generating enzymes implicated in cardiovascular disease. Nox4 is the most abundantly expressed isoform in endothelial cells but its function remains unknown. We investigated the role of endothelial Nox4 on vascular function and blood pressure (BP) in vivo.

    Methods and Results

    We generated transgenic mice with endothelium-specific overexpression of Nox4 (Nox4TG) and studied the effects on endothelial function (aortic …

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