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Frailty: the great confounder, the great forgotten
  1. R Romero-Ortuno
  1. Correspondence to Dr Roman Romero-Ortuno, Department of Medicine for the Elderly, St James's Hospital, James's Street, Dublin 8, Ireland; romeror{at}

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To the Editor: Ryan et al1 present the results of SAFE PACE-2, which are at odds with SAFE PACE-1.2 The authors discuss that this may be due to greater frailty in SAFE PACE-2 participants. This point is valid and merits further reflection in relation to recent frailty literature.

Frailty is a well-recognised clinical syndrome, it but remains difficult to define and measure. Central to the concept of frailty is …

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; not externally peer reviewed.