Background The Amplatzer duct occluder (ADO) has been used with success to close large patent ductus arteriosus (PDA), but some problems exist especially with hypertensive PDAs, such as incomplete closure, haemolysis, left pulmonary artery stenosis, obstruction of the descending aorta and progressive pulmonary vascular disease.
Methods and results We analysed a group of 168 patients with isolated PDA and pulmonary artery systolic pressure (PSAP) ≥50 mm Hg. Mean age was 10.3 ± 14.3 years (median 3.9), PDA diameter was 6.4 ± 2.9 mm (median 5.9), PASP was 63.5 ± 16.2 mm Hg (median 60), Qp/Qs was 2.7 ± 1.2 (median 2.5), total pulmonary resistance index (PRI) was 3.69 ± 2.15 (median 3.35) and vascular PRI was 2.73 ± 1.72 (median 2.37). We used ADOs in 145 (86.3%) cases, Amplatzer muscular ventricular septal defect occluders (AMVSDO) in 18 (10.7%), Amplatzer septal occluders (ASO) in three (1.8%) and the Gianturco-Grifka device in two (1.2%) cases. Device diameter was 106.3% ± 51% higher than PDA diameter. PASP decreased after occlusion to 42.5 ± 13.3 mm Hg (p<0.00001). Immediately after closure, no or trivial shunt was present in 123 (74.5%) cases. Immediate complications were device embolisation in five (3%) cases and descending aortic obstruction in one case. The overall success rate was 98.2%. Follow-up in 145 (86.3%) cases for 37.1 ± 24 months (median 34.1) showed further decrease of the PASP to 30.1 ± 7.7 mm Hg (p<0.0001).
Conclusions Percutaneous treatment of hypertensive PDA is safe and effective. ADO works well for most cases, but sometimes other devices (MVSDO or ASO) have to be used. When cases are selected adequately, pulmonary pressures decrease immediately and continue to fall with time.
- Ductus arteriosus
- patent heart defects
- congenital hypertension
- pulmonary catheterisation occlusion
- paediatric interventional cardiology
- device closure
- pulmonary arterial hypertension (PAH)
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.