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Serial angiographic surveillance data and the importance of overall TLR
  1. Robert A Byrne
  1. Correspondence to Robert A. Byrne, ISAR Centre, Deutsches Herzzentrum München, Lazarettstrasse 36, 80636 Munich, Germany; byrne{at}

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The author's reply: We thank Dr Kaneda for raising an important issue in relation to the 2-year results of the ISAR-TEST-3 randomised trial.1 Missing data is a pervasive feature of angiographic follow-up studies in general as rates of surveillance angiography are always less than 100% in large clinical trials. This data is regarded as missing not at random,4 and the amount of error introduced is related to a number of factors including the sample size, the actual rate of angiographic follow-up and the absolute rate of restenosis.5 Notwithstanding this, angiographic markers of restenosis have proven to be robust surrogates of clinical stent efficacy and—within certain constraints—generally …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; not externally peer reviewed.

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