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Clinical and research medicine: Cardiovascular clinical pharmaceutical research
e0361 Effect on electrolytic to combining application of calcium channel blocker (CCB) and diuretic for general hypertensives
  1. Xie Xiaobing,
  2. Hong Jing,
  3. Tao Sha,
  4. Li Nanfang
  1. Hypertension Unit of The People's Hospital of Xinjiang Uygur Autonomous Region, The Institute of Hypertension of Xinjiang, The Center of Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region


Introduction To evaluate the effects of low-dose applications of dihydrochlorothiazede (DHCT) or DHCT and nitrendipine on blood pressure, heart rate, and serum electrolytes in hypertensives in Xinjiang agriculture-pasture region.

Method Administer low dose DHCT two weeks of hypertensive disease in basic level region, according to blood pressure reach standard, combining nitrendipine (68 subjects), keep on low dose DHCT (67 subjects), follow-up visit for 3 months, to observe change of electrolytic and blood pressure (BP), heart rate (HR).

Result BP and HR decreased significantly after antihypertensive drug therapy compared with the baseline level each regimen (p<0.05). According to the post-treatment by trimenon, Blood sodium of each regimen after antihypertensive drug therapy was lower than that before antihypertensive drug therapy, p<0.05. There were no statistical differences in changes of electrolytic (Na+, K+ and Ca+)between two regimens, p>0.05.

Conclusion They can lead to hyponatremia low dose regimen of DHCT and combiniant nitrendipine towards to hypertensive disease in basic level region. But on the basis of low dose regimen of DHCT combining nitrendipine is not to further increase the electrolytic turbulence.

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