Objective To investigate the clinical significance of myeloperoxidase (MPO)and paraoxonase (PON1) in coronary heart disease (CHD).
Methods We chossed 300 hospitalised coronary heart disease patients according to the results of selective coronaryangiography. Then, we divided them into coronary heart disease group (n=240)and control group (n=60). Coronary heart disease group were divided into stable angina pectoris (SAP) group (n=60)and acute coronary syndrome (ACS) group (n=180) according to clinical diagnosis. Coronary heart disease group were divided into group A, group B and group C according to type of coronary artery disease's pathological changes. We grade the lesions of coronary artery by means of Gensini coronary score system. The day after admission fasting. MPO and PON1 test specimens taken from coronary arterial blood was collected via the sheath and put into anticoagulant tube. the serum MPO were detected by colourimetry method and the PON1 concentration level was detected by pheny acetate method. All cases were asked about both history and physical examination to rule out malignancy, liver fibrosis, recent surgery, severe infection, acute cerebrovascular disease, peripheral vascular disease and so on.
Results The level of MPO in CHD group was significantly higher than that in the control group, and the level of PON level was significantly lower than that in the control group. In ACS group, MPO level was also significantly higher than that in SAP group, and the PON level was significantly lower than that in the SAP group. When the CHD is more severer, the MPO level will be more higher and the level of PON will be more lower. With coronary artery disease type and the severity of coronary artery disease, MPO levels increased gradually, while the PON level decreased gradually, stepwise regression analysis showed that MPO, PON, HDL, LDL concentrations were related significantly with the Gensini score of coronary lesions.
Conclusion MPO, PON1 would be better indicators to reflect the local inflammation of atherosclerotic plaque, LDL can affect the conversion of ox-LDL by MPO, PON1. So that, it can be the key mechanism of atherosclerotic plaque's stability. Through detection of serum pro-inflammatory factor (MPO), and anti-inflammatory factor (PON1) levels in CHD patients and investigate their relationship with CHD and coronary artery disease, further analysis of the imbalance of pro-inflammatory cytokines and anti-inflammatory factor may be particularly important in the pathological significance in coronary heart disease, especially in acute coronary syndrome, and provide a new basis for the diagnosis and prediction of coronary heart disease and coronary artery disease.
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