Objective To study the clinical profile of premenopausal women with coronary heart disease.

Methods 116 premenopausal women with chest pain were classified into coronary heart disease group and control group by coronary angiography. Risk factors, clinical symptoms and the coronary angiographic characteristics were investigated retrospectively.

Results The risk factors of premenopausal women with coronary heart disease were hypertension, diabetes and hyperlipidaemia. Typical angina pectoris was an important character. The typical change of ECG in premenopausal women with coronary heart disease was elevation or depression of ST, but not T wave. The sensitivity and specificity of Exercise stress testing or SPECT for premenopausal women with coronary heart disease were 67.7% and 32.2%, 40.9% and 59%, respectively. Single vessel coronary lesion was found more frequently in Premenopausal Women with coronary heart disease, and the left anterior disending artery was the most frequently involved vessel.

Conclusion Hypertension, Diabetes and/or hyperlipidaemia are major risk factors in premenopausal women with coronary heart disease. Women with typical angina pectoris and ST changes should be cautioned coronary heart disease. Nonvasive testing is a poor diagnosis method for young women with coronary heart disease, but can be used as exclusive marker.