Objective 1. To investigate the relationship between sleep apnea syndrome (SAS) and myocadial ischaemic events in patients with coronary heart disease (CHD). 2. To compare the differences of age, gender distribution, coronary angiography results in CHD patients with and without SAS. 3. To compare the differences of C-reactive protein (CRP) and haemoglobin levels in CHD patients with and without SAS.
Methods 25 CHD patients with typical symptoms of angina and ECG changes were enrolled in this study. After overnight polysomnography (PSG), all the cases were monitored by portable device at night for 7 days in order to exclude the conditions that the cases did not sleep or had waked, apnea and hypopnoea events were recorded during 24: 00–4:00. Blood samples were collected 5–10 min after monitoring, and the levels of haemoglobin and C-reactive protein were examined.
Results 1. The incidence of myocardial ischaemia caused by apnea and low ventilation was significantly higher in CHD patients with SAS. 2. There were significant differences between the two groups in the decrease of oxygen desaturation and the increase of heart rate. 3. BMI in CHD patients was significantly higher in those with SAS. There were more multi-vessel lesions and long lesions in CHD patients with SAS (p<0.05). The level of haemoglobin and C-reactive protein were much higher in CHD patients with SAS.
Conclusion 1. The incidence of SAS is much higher in patients with CHD, and the incidence of myocardial ischaemic events is higher in CHD patients with SAS. and the more seriuos respiratory disorders, the more easily myocardial ischaemia happens. With apnea related to myocardial ischaemia and oxygen reduction, has nothing to do with the heart rate. 2. Lesions of SAS in patients with coronary heart disease are heavier than Simple CHD group in coronary angiography. BMI of SAS in patients with coronary heart disease are high than Simple CHD group. 3. The levels of CRP and haemoglobin are higher in CHD patients with SAS.