Objective To investigate the effects of cholesterol-lowering therapy with rosuvastatin calcium tablet on coronary flow reserve (CFR) patients with unstable angina pectoris (UAP) and hypercholesterolaemia.

Method 40 patients with UAP were randomly divided into rosuvastatin calcium tablet therapeutic group (n=20) and conventional therapeutic group (n=20). By using colour Doppler ultrasound the coronary flow reserve was measured in patients with UAP before and after 3 rnonths cholesterol-lowering therapy.

Result After cholesterol-lowering therapy for 3 months the serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG)decreased significaroly p<0.01. The coronary flow, reserve was increased from 1.92±0.41 to 2.97±0.62 (p<0.01). An inverse correlation was found not only between TC and C FR (r=−0.44, p<0.05) but also between LDL-C and CFR (r=0.47, p<0.05).

Conclusion Cholesterol-lowering therapy with rosuvastatin calcium tablet may improve coronary flow reserve in patients with UAP and hypercholesterolaemia.