Background Few studies have focused on the change of health-related quality of life following acute coronary syndrome, to compare of oral medical therapy, percutaneous coronary intervention and coronary artery bypass grafting. The objective of this study was to identify the changes in Health Related Quality of Life 6 months after discharge from hospital in patients with acute coronary syndrome, and to determine next therapy strategy.

Methods Health Related Quality of Life was assessed in 389 consecutive patients with acute coronary syndrome at the admission and 6 months after discharge which used the Seattle angina questionnaire. To identify the variables associated with the changes, logistic regression models were constructed for five summary dimensions of the Seattle angina questionnaire taking the changes in the score of the dimension as dependent variable.

Results Used the Seattle angina questionnaire scores, all three treatment groups experienced relief of angina at the 6-month visit compared with baseline. At 6 months, in physical limitation, angina stability, angina frequency, percutaneous coronary intervention group and coronary artery bypass grafting group had more significant improvements than Oral medical therapy group (p<0.001). When compared the firstly two group, Coronary artery bypass grafting group had more significant improvements than percutaneous coronary intervention group in angina frequency (p=0.002), treatment satisfaction (p=0.001) and quality life (p=0.002).

Conclusions In patients with acute coronary syndrome, percutaneous coronary intervention group and coronary artery bypass grafting group can provide greater gain in quality life than oral medical therapy, CABG can improve more quality life.