The prognosis of patients with chronic total occlusion (CTO) and diabetes mellitus treated with percutaneous coronary intervention (PCI) is not well known.
Methods From Jan 2001 to April 2009, 105 cases of CTO successfully treated with PCI were included. 31 patients with diabetes and 74 without diabetes were compared for angiographic and clinical outcomes (mean follow up 36±21 month). Death, myocardial infarction and repeat PCI or coronary artery bypass surgery were considered as a combined primary endpoint.
Results 25 diabetes patients (78%) and 67 non-diabetic patients (89%) were treated by drug eluting stent (p=0.37). The primary endpoint occurred in 22% (n=7) of diabetes patients, 10.8% (n=8) of the patients without diabetes (p=0.059; Log rank test), Cox regression showed patients with diabetic group and moderately or severely reduced renal impairment had significant increased risk for MACE (HR: 6.34, 95% CI 2.06 to 19.56, p<0.001).
Conclusions Our study showed patients with CTO and diabetes have a tendency of poor prognosis after PCI, which may be largely due to the complicated renal impairment.