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Clinical and research medicine: Interventional cardiology
e0485 Clinic study of domestic tirofiban on TIMI Flow during facilitated PCI
  1. Guo Lai-jing1,
  2. Hu Dayi1,
  3. Huo Yong1,
  4. Tang Qiang1,
  5. Zhang Huiying1,
  6. Xing Liying1,
  7. Wang Zhi1,
  8. Qu Huaqing2,
  9. Shi Zhentao1,
  10. Zhu Zhenzhong3,
  11. Yan Do1,
  12. Tang Qunzhong1,
  13. Chen Xuezhi1,
  14. Liu Xiumin1
  1. 1Department of Cardiology Beking University Shougang Hospital
  2. 2Department of Cardiology Beking University Shougang Hospital
  3. 3Department of Emerergency Beking University Shougang Hospital


Objective To assess Thrombolysis In Myocardial Infarction (TIMI) flow of the nation-produced tirofiban in patients with ST-segment elevation myocardial infarction (STEMI) during primary Percutaneous Coronary Intervention (PCI).

Methods 120 patients with STEMI during primary PCI from Nov 2006 to June 2009 were divided into two groups, tirofiban+PCI group of 60 cases (51 males and 9 females) with mean age (60.11±10.96) years old, and the other primary PCI group of 60 cases (42 males and 18 females) with mean age (64.33±11.91) years. The TIMI flow before and after operation were observed in all cases angiographically.

Results By using tirofiban before operation improved TIMI flow, a greater percentage of TIMI 1 grade flow was achieved in the tirofiban+PCI group compared with the primary PCI group before operation (13.3.8% vs 3.3%, p>0.05). There was no difference of TIMI 3 grade flow between the two groups after operation, TIMI 2 grade flow was lesser in tirofiban+PCI group (6.7% vs 3.4%, p>0.05).Reperfusion arrhythmia was lesser in tirofiban+PCI group (3.4% vs 6.7%).

Conclusion Tirofiban may improve TIMI flow of the IRA in patients with STEMI during emergency PCI.

  • Myocardial infarction
  • platelet glycoprotein IIb/IIIa receptor antagonists
  • angioplasty, transluminal, percutaneous coronary artery, Thrombolysis In Myocardial Infarction (TIMI), elevation myocardial infarction (STEMI), Percutaneous Coronary Intervention (PCI)

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