Objective To investigate the clinical safety and mid-and short-term efficacy of rapamycin eluting stent (Excel) in patients with coronary artery disease.

Methods Between Jul. 2006 and Jun. 2009, 240 patients of coronary heart disease received percutaneous coronary intervention (PCI) with Excel stent and were followed up from 6 to 24 months for observing the incidence of angina pectoris, myocardial infarction, sudden death and revascularization.

Results 327 pieces of Excel stent were implanted in 272 target lesions (269 with de novo and 3 of restenosis), but 2 cases failed due to seriously deformed middle anterior descending artery from calcification in 1 and the angle of middle circumflex branch larger than 90 degrees in another to prevent the passage. 325 pieces of stent were successfully implanted, and the postoperative follow-up in the 8^th to 18^th month showed that angina pectoris occurred in 5, restenosis in 2 and normal in 3 by coronary arteriongraphy, suspected thrombosis in 1 at the 5^th month after the operation regarding ventricular fibrillation, haemorrhage of upper digestive tract in 4 at the 6^th month of the intervention, in which 1 underwent inpatient therapy with blood transfusion. The postoperative major coronary adverse event accounted for 4.58% between 6 and 24 months.

Conclusion Excel drug-eluting stent may be excellent in treatment of coronary artery diseases with regard to its safety and mid-and short-term effect.