Objective To explore the feasibility and clinical effects by transcatheter interventions used for the patient suffering acute myocardial infarction (AMI) complicating with ventricular septal rupture (VSR) postinfarction.

Methods Between June 2005 and August 2009, Ventricular septal rupture (VSR) patients diagnosed with VSR underwent transcatheter closure aged 59–79 years old (mean 63.3±24.7). The occluders were released with the monitoring of transthoracic echocardiography (TTE) and X-ray fluoroscopy.

Results 3 cases were successfully treated with transcatheter closure. The defect diameter was 11–28 (17±9.5) mm measured by TTE and the size of the occluder was 16–32 (21.3±7.6) mm. The occluder successful rate was 100%. The case success in 2 and a big VSR lead to die in 1.

Conclusions VSR was showed by praecordial area auscultation, transthoracic echocardiography (TTE) and left ventricular angiography after AMI. The transcatheter closure of VSR postinfarction is alternative method in patients not suite for surgical closure. But the careful examination and preparation are need before transcatheter closure.