Objective To compare the influence of different clinical factors on the HRV time domain, frequency-domain indicators and the strength and type of influence.

Methods A retrospective study on the long-time HRV time domain, frequency domain values of 192 patients with diabetes, coronary heart disease (CHD), hypertension, cancer and cervical spondylosis (CS), to observe the strength and type of each factor when there are multiple factors simultaneously using multiple linear regression statistical method.

Results In different age patients with complications of diabetes, CHD, hypertension, cancer and CS, the significant influencing factors on HRV were age, diabetes and CS. Made SDNN values as the dependent variable, enrolled the final regression equation was in turn age (β=−0.282, p<0.001), diabetes (β=−0.237, p<0.001) and CS (β=0.151, p=0.024); Made SDANN values as the dependent variable, enrolled the final regression equation was also in turn age (β=−0.271, p<0.001), diabetes (β=−0.236, p=0.001) and CS (β=0.142, p=0.036); Made LF values as the dependent variable, enrolled the final regression equation was also in turn age (β=−0.364, p<0.001), diabetes (β=−0.216, p=0.001) and CS (β=0.138, p=0.034); Made TP values as the dependent variable, enrolled the final regression equation was only age (β=−0.285, p<0.001) and diabetes(β=−0.174, p=0.011); Made HF values as the dependent variable, enrolled the final regression equation was also age (β=−0.277, p<0.001) and diabetes(β=−0.162, p=0.020); which meaning age and diabetes were a negative correlation with SDNN, SDANN, TP and LF, while CS was positively correlated with SDNN, SDANN and LF. Only diabetes had significant influence on RMSSD, it was negatively correlated with RMSSD (β=−0.148, p=0.040).

Conclusion Age increase and having diabetes will significantly reduce the overall tension of autonomic nervous and sympathetic tone, and diabetes can significantly lower vagal tone factor.