Objective To observe losartan combining with amiodarone and shensongyangxin capsule on maintain sinus rhythm with hypertension after atrial fibrillation reversion.
Methods 105 patients with hypertention after atrial fibrillation reversion were randomly divided into three groups. Group A was treated by amiodarone; Group B was treated by amiodarone and losartan; Group C was treated by amiodarone combining with losartan and shensongyongxin capsule. All patients were treated with general anti-hypertension therapy except ACEI and ARB. All patients were examined with UCG and Holter monitor before and after 12 months' therapy.
Results The left atrial dimension of the patients in Group B and Group C were smaller than those in Group A (p<0.05), the rates of maintaining sinus rhythm in Group B and Group C were higher than those in Group A (p<0.05, p<0.01), especially the Group C which was even more obvious (p<0.01).
Conclusion Amiodarone and losartan should be used to treat the patients with hypertension and atrial fibrillation, losartan also has definite curative effect in maintaining sinus rhythm. However combined with shensongyanxin capsule, the effect should be better.
- Shensongyanxin capsule
- atrial fibrillation
- sinus rhythm
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