Introduction The purpose of the present study was to assess the possible association between CREG and CAD in the Han population of North China.

Methods ALL five selected SNPs were genotyped in 1161 patients with angiographically documented CAD and 960 control subjects free from CAD who had normal coronary angiograms. Patients and controls were unrelated individuals of Han Chinese from the northeast region of China, genotype analyses were performed additive, dominant and recessive models. Binary logistic regression was used to control for the presence of vascular risk factors both in genotype and haplotype analyses.

Results Genotype frequencies of the five examined polymorphisms were similarly distributed between CAD group and controls (p>0.05). Further haplotype analysis also found no significant differences in the distributions between CAD group and controls (p>0.05).

Conclusion This study did not show a statistically significant association between common variants of CREG and CAD in northern Chinese Han population.