Introduction To study the relationship between T3593C polymorphism in the α subunit gene of epithelial sodium channel (ENaC) with essential hypertension (EH) and serum electrolytes of Xinjiang Kazakhs.

Methods More than 500 Xinjiang Kazakhs aged more than 30 years were recruited by cluster sampling from the pasture area of Xinjiang and were divided into hypertensives (EH group) and normotensives (NT group). The genotypes of T3593C were determined by PCR-RFLP method and the serum electrolytes were measured.

Results The frequencies of TT, TC, CC genotypes were 88.39%, 10.63%, 0.98% and the alleles frequencies of T, C were 93.7%, 6.3%, respectively. The distributed genotypic frequencies of TT, TC, CC were 89.33%, 9.88%, 0.79% in EH group and 87.45%, 11.37%, 1.18% in NT group, respectively. The genotypic and allelic frequencies were not different between EH group and NT group (p=0.78; p=0.46). There was no significant difference in levels of blood pressure and serum electrolytes between subjects with the TT and TC+CC genotypes (p>0.05). The T3593C polymorphism were excluded as independent variables which related to the blood pressure and serum electrolytes of subjects controlling FPR age and gender by multiple logistic analysis.

Conclusions The T3593C polymorphism might not be associated with EH and serum electrolytes of Xinjiang Kazakhs.