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Syncope following ‘pill-in-the-pocket’ treatment of atrial fibrillation with propafenone plus quinidine
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- Published on: 23 November 2015
- Published on: 23 November 2015Death following "pill-in-the-pocket" treatment with propafenone and verapamil in a CYP2D6 poor metaboliserShow More
To the Editor Daniell [1] reports a case of syncope after "pill-in-the-pocket" treatment with propafenone. He mentions the CYP2D6 metabolism of propafenone and the possible interaction with CYP2D6 inhibitors. We would like to further illustrate the potential risks of propafenone in CYP2D6 poor metabolisers with the case of a 70 year-old woman who died from sudden cardiac arrest after taking 600 mg of propafenone orally for...
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