Acute coronary syndromes
High-dose tirofiban pretreatment reduces the need for bail-out study medication in patients with ST-segment elevation myocardial infarction: results of a subgroup analysis of the On-TIME 2 trial
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To the Editor: We appreciate the work by Hermanides et al, which reported that routine prehospital treatment with high-dose tirofiban (HDT) significantly reduced the use of blinded bail-out study medication (20% vs.29%). The need for bail-out therapy was associated with a less favourable outcome (major adverse cardiac events (MACE) at 30 days 12.2% vs 5.6%). This analysis suggests that routine pretreatment is superior to...