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The Authors' reply
  1. Daniel Lasserson1,
  2. Thierry Buclin2,
  3. Paul Glasziou3
  1. 1Primary Care Health Sciences, University of Oxford, Oxford, UK
  2. 2Division of Clinical Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland
  3. 3Centre for Research in Evidence-Based Practice, Bond University, Robina, Queensland, Australia
  1. Correspondence to Dr Daniel Lasserson, Primary Care Health Sciences, University of Oxford, Oxford OX1 2ET, UK; daniel.lasserson{at}

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The Authors' reply We thank Dr Marshall1 for this opportunity to expand on our conclusions.2 While agreeing with our main findings, his critique of our suggestion about rapid titration has, to an extent, been addressed in the article where we outlined the limitations of our conclusions and suggested that an individual patient data meta-analysis would advance …

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