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Do statins improve outcomes and delay the progression of non-rheumatic calcific aortic stenosis?
  1. Alessandro Parolari1,
  2. Elena Tremoli1,2,
  3. Laura Cavallotti1,
  4. Matteo Trezzi1,
  5. Samer Kassem1,
  6. Claudia Loardi1,
  7. Fabrizio Veglia1,
  8. Giovanni Ferrari3,
  9. Davide Pacini4,
  10. Francesco Alamanni1
  1. 1Unit for Clinical Research in Atherothrombosis, Centro Cardiologico Monzino IRCCS; Department of Cardiovascular Sciences, University of Milan, Milan, ITALY
  2. 2Department of Pharmacological Sciences, University of Milan, Milan, ITALY
  3. 3Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA
  4. 4Department of Cardiac Surgery, S Orsola-Malpighi Hospital, University of Bologna, Bologna, ITALY
  1. Correspondence to Dr Alessandro Parolari, Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milano, Italy; alessandro.parolari{at}


Context It is not known whether statin treatment improves clinical outcomes and reduces aortic stenosis progression in non-rheumatic calcific aortic stenosis.

Objective A meta-analysis of studies was performed comparing statin therapy with placebo or no treatment on outcomes and on aortic stenosis progression echocardiographic parameters.

Data sources The authors searched Medline and Pubmed up to January 2010.

Data extraction Two independent reviewers independently abstracted information on study design (prospective vs retrospective or randomised vs non-randomised), study and participant characteristics. Fixed and random effects models were used. A-priori subanalyses assessed the effect of statins on low-quality (retrospective or non-randomised) and on high-quality (prospective or randomised) studies separately.

Results Meta-analysis identified 10 studies with a total of 3822 participants (2214 non-statin-treated and 1608 statin-treated); five studies were classified as prospective and five as retrospective; concerning randomisation, three trials were randomised whereas seven were not. No significant differences were found in all-cause mortality, cardiovascular mortality or in the need for aortic valve surgery. Lower-quality (retrospective or non-randomised) studies showed that, in statin-treated patients, the annual increase in peak aortic jet velocity and the annual decrease in aortic valve area were lower, but this was not confirmed by the analysis in high-quality (prospective or randomised) studies. Statins did not significantly affect the progression over time of peak and mean aortic gradient.

Conclusions Currently available data do not support the use of statins to improve outcomes and to reduce disease progression in non-rheumatic calcific aortic valve stenosis.

  • Aortic valve disease
  • meta-analysis
  • non-rheumatic calcific aortic stenosis
  • statins
  • statistics
  • surgery-valve
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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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