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Coronary heart disease mortality trends in the Netherlands 1972–2007
  1. I Vaartjes1,
  2. M O'Flaherty2,
  3. D E Grobbee1,
  4. M L Bots1,
  5. S Capewell2
  1. 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
  2. 2Division of Public Health, University of Liverpool, Liverpool, UK
  1. Correspondence to I Vaartjes, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (STR 6.131), Postbox 85500, 3508 GA Utrecht, Netherlands; c.h.vaartjes{at}


Background Coronary heart disease (CHD) mortality has steadily declined since the early 1970s in the Netherlands. However, in some Western countries the rate of decline in younger groups may be starting to plateau or even rise.

Objective To examine trends in age-specific CHD mortality rates among Dutch adults from 1972 to 2007, with a particular focus on recent trends for the younger age groups

Methods Data for all CHD deaths (1972–2007) in the Netherlands were grouped by year, sex, age. A joinpoint regression was fitted to each age-sex-group to detect points in time at which significant changes in the trends occur. For every time period, the linear slope of the trend, p value, observed number of deaths, CHD mortality rates and change in the CHD mortality rate were calculated.

Results Between 1972 and 2007, the age-adjusted CHD mortality rates decreased overall by 76% in both men and women. In men (35–54 years), the change in CHD mortality rate in the period 1980–1993 was −0.53 but attenuated in period 1993–1999: −0.16. In women (35–54 years) the decline likewise attenuated to −0.44 in period 1979–1989: and −0.05 in period 1989–2000. After 1999–2000, CHD mortality rate further declined in both men (period 1999–2007: −0.46) and women (period 2000–2007: −0.38).

Conclusions Evidence from several Western countries suggests that among young adults (<55 years), CHD mortality rates are levelling out. In this study, similar attenuation of the decline in CHD mortality among young adults in the Netherlands has been observed. Furthermore, this is the first study to observe a subsequent increase in the pace of decline after a period of flattening. In order to better explain these encouraging changes in CHD mortality rates, a detailed analysis of recent changes in cardiovascular risk factors and treatments is now urgently required.

  • Epidemiology

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  • Funding IV was funded by the Netherland Heart Foundation (grant NHF project Facts and Figures). The funding source had no involvement in the study design, collection, analysis and interpretation of data, writing of the report and decision to submit the paper for publication.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.