Article Text


Heart failure and left ventricular function
Relation of QRS duration and TNFα in patients with cardiac desynchronisation in chronic heart failure
  1. Zhang Zhengxun,
  2. Liu Xincan,
  3. Chen Xiaoling,
  4. Li Shengjun,
  5. Zhang Xiaoyi,
  6. Wang Honghui
  1. The First Affiliated Hospital of Henan University of Tcm


Objective To investigate the sensitivity of tumour necrosis factor α (TNFα), QRS duration and the parameter of cardiac function in evaluating cardiac desynchronisation.

Methods A total of 268 patients with chronic heart failure (CHF) were enrolled. Selection criteria included patients with optimal pharmacological treatments, New York Heart Association (NYHA), left ventricular ejection fraction (LVEF) <35%. All enrolled patients underwent the following checks: electrocardiography (ECG); TNFα; M-echocardiography: mensured the SP-WMD and SLD, SP-WMD≥130 ms and/or SLD≥60 ms is defined intraventricular desynchronisation. Ventricular desynchronisation (VD) includes SP-WMD≥130 ms and/or SLD≥60 ms. Patients with QRS≥120 ms are A group, including A1 (VD) subgroup and A2 (non-VD) subgroup. Patients with QRS 0. 05).

Conclusion QRS duration is not a only marker to evaluate VD, and the patients with narrow QRS in heart failure also present VD. There is a good correlation between QRS duration and TNFα, and the combination of QRS duration and TNFα can increase the sensitivity to detect VD.

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