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Biomarkers and laboratory testing for cardiovascular disease>
Increased ambulatory arterial stiffness index correlated with monocyte chemoattractant protein-1 in prehypertensives
  1. Zhendong Liu,
  2. Fanghong Lu,
  3. Yuanli Dong,
  4. Shujian Wang,
  5. Yingxin Zhao,
  6. Shangwen Sun,
  7. Hui Pan
  1. Cardio-Cerebrovascular Control and Research Center, Shandong Academy of Medical Sciences, The First Hospital of Lanshan, Linyi, Shandong, China


Objective To investigate increased ambulatory arterial stiffness index correlated with plasma level and expression of monocyte chemoattractant protein-1.

Methods One hundred and eight subjects with prehypertension and 101 optimal normotensive subjects were eligible enrolled. Non-invasive ambulatory blood pressure monitoring was performed using automatic devices (TM-2421 and TM-2430; A&D, Tokyo, Japan) and ambulatory arterial stiffness index was calculated in all participants. Monocyte chemoattractant protein-1 expression was conducted by quantitative real-time reverse transcription-PCR (RT-PCR).

Results Ambulatory arterial stiffness index was 0.48±0.10% in prehypertensives, higher than that in optimism normotensives (t value=10.689, P-1 in prehypertensives.

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