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Cardiovascular disease basic research
Rotigaptide remodels Connexin 43 expression in a prolonged ventricular-fibrillation in swine
  1. Li Jingsha,
  2. Zhong Jingquan,
  3. Zeng Qixian,
  4. Liu HongzhenQilu
  1. Hospital of Shandong University, Ji'nan, Shandong Province, China


Objective In the present study the effect of ZP123 on different-duration VF was evaluated by analysing VF mean frequency (VFmf) and amplitude (VFma).

Methods Twenty pigs randomly received either ZP123 (drug group: 10 μg/kg/h; n=10) or saline infusion (control group: 50 ml/h, n=10) over 15 min before VF electrically induced. VFmf and VFma obtained from electrocardiography were analysed by a multipurpose polygraph. Haemodynamics, the rate of the first three successful defibrillation and return of spontaneous circulation (ROSC) were recorded.

Results In drug versus control animals, VFmf during the whole 8-minute VF was 11.8±2.1 Hz vs 10.4±2.0 Hz (p<0.05), VFma was 0.24±0.10 V vs 0.31±0.16 V (p<0.05) and hemodynamic during VF in the two groups were comparable (p>0.05). There was no difference in the rate of successful defibrillation and ROSC between the two groups (p>0.05). However, in the first 4 min, VFmf of the drug group was higher (p<0.05) and VFma was roughly equal to that of control group (p >0.05). Hemodynamic of the first 4 min in the drug group was higher (p<0.05).

Conclusion while ZP123 could not improve the rate of successful defibrillation and ROSC in prolonged VF, it may still play a positive role in short-duration VF no more than 4 min.

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