Article Text

Download PDFPDF

Successful transcatheter aortic valve implantation (TAVI) is associated with transient left ventricular dysfunction
  1. Rafal Dworakowski,
  2. Olaf Wendler,
  3. Amit Bhan,
  4. Lindsay Smith,
  5. Peter Pearson,
  6. Emma Alcock,
  7. Kailasam Rajagopal,
  8. Beth Brickham,
  9. Tracy Dew,
  10. Jonathan Byrne,
  11. Mark J Monaghan,
  12. Roy Sherwood,
  13. Ajay M Shah,
  14. Philip A MacCarthy
  1. King's College London BHF Centre of Excellence, Department of Cardiology, King's College Hospital, London, UK
  1. Correspondence to Dr Philip MacCarthy, Consultant Cardiologist, Department of Cardiology, King's College Hospital, Denmark Hill, London SE5 9RS, UK; philip.maccarthy{at}


Objective To investigate early haemodynamic changes after transfemoral transcatheter aortic valve implantation (TAVI) and the relationship with myocardial injury and neurohormonal activation.

Design Single-centre prospective observational study.

Setting Tertiary cardiac centre.

Patients 42 patients undergoing transfemoral TAVI were included in this study.

Main outcome measures Haemodynamic measurements and echocardiography-derived indices characterising myocardial function were recorded at baseline, 6 and 24 h postprocedure. Postprocedural myocardial injury was quantified using serum troponin I and CK-MB levels. In addition, biomarkers of myocardial dysfunction/heart failure and neurohormonal activation were measured.

Results 6 h Post-TAVI there was a significant deterioration in both systolic and diastolic function as measured by dP/dtmax/EDV, myocardial performance index and mean E/e' index. Recovery of myocardial function was observed at 24 h. These haemodynamic changes were associated with a significant increase in both troponin I (0.07±0.01 vs 1.59±0.21 μg/l, p<0.005) and CK-MB (1.99±0.19 vs 6.82±0.7 ng/ml, p<0.005). There was a positive correlation among myocardial injury and NT-BNP (r=0.34, p<0.0005), aldosterone (r=0.56, p<0.0001) and ST2 levels (r=0.21, p<0.05).

Conclusions This is the first study to demonstrate that procedurally successful TF-TAVI results in a transient depression of both systolic and diastolic left ventricular function within the first 24 postoperative hours, despite impressive relief of previously severe, chronic pressure overload. The rise in the markers of myocardial damage suggests that this may be due to periprocedural myocardial injury. Complete recovery of contractility is generally observed after 24 h.

  • Severe aortic stenosis
  • transcatheter aortic valve implantation
  • myocardial function
  • myocardial injury
  • coronary artery disease
  • coronary physiology
  • endothelium
  • oxidative stress
  • interventional cardiology
  • valvular disease
  • aortic valve disease
  • aorta
  • great vessels and trauma
  • cardiac surgery
  • pericardial disease
  • mitral regurgitation
  • imaging and diagnostics
  • echocardiography
  • allied specialities
  • anaesthetics
  • cardiac function
  • left ventricular hypertrophy
  • free radicals
  • fractional flow reserve
View Full Text

Statistics from

Supplementary materials

  • Philip MacCarthy discusses the research with Alistair Lindsay in the Heart podcast

    Listen to the podcast


    • Funding This study was supported by the King's College Hospital NHS Foundation Trust R&D Initiative Grant.

    • Competing interests None.

    • Ethics approval Ethics approval was provided by the King's College Hospital Ethics Committee.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.