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Problems with epidemiological approach and conclusions-the response
  1. Sabine Rohrmann1,
  2. Jakob Linseisen2,
  3. Rudolf Kaaks3,
  4. Kuanrong Li3
  1. 1Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zürich, Switzerland
  2. 2Institute of Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany
  3. 3Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
  1. Correspondence to Professor Sabine Rohrmann, Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Hirschengraben 84, Zürich CH-8001, Switzerland; sabine.rohrmann{at}

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The Authors’ reply We are not surprised by the controversy caused by our recently published paper in Heart,1 showing that taking calcium supplements might roughly double the risk of myocardial infarction (MI) among middle-aged and elderly adults. Our paper contributes to the ongoing debate evoked by previous meta-analyses of clinical trials,2 ,3 in particular, which alarmed the public that calcium supplements might also provide unfavourable health effects.

We would like to rectify a few of the criticisms by Prince.2 First, we confirm that, contrary to Dr Prince's reading of our manuscript, we did, in fact, verify systematically all self-reported disease outcomes, that is, MI, stroke and cardiovascular deaths, against …

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  • Contributors KL: data analysis, result interpretation and manuscript writing. JL, RK and SR: reviewed and commented on the manuscript. RK: administrative and financial support.

  • Funding This paper is funded by Deutsche Krebshilfe (grant-No 70-488-Ha I) and the Graduiertenkolleg 793: Epidemiology of communicable and chronic non-communicable disease and their inter-relationships.

  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.