Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker

Karel G M Moons; Andre Pascal Kengne; Mark Woodward; Patrick Royston; Yvonne Vergouwe; Douglas G Altman; Diederick E Grobbee

doi:10.1136/heartjnl-2011-301246

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Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker

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Mar 2012	296	51	68
Apr 2012	758	62	138
May 2012	471	55	121
Jun 2012	252	39	60
Jul 2012	213	60	78
Aug 2012	109	36	56
Sep 2012	101	33	47
Oct 2012	210	40	73
Nov 2012	124	95	60
Dec 2012	86	34	29
Jan 2013	131	52	74
Feb 2013	159	94	47
Mar 2013	268	121	51
Apr 2013	224	39	40
May 2013	209	59	43
Jun 2013	206	54	47
Jul 2013	232	106	53
Aug 2013	292	95	47
Sep 2013	243	71	49
Oct 2013	342	71	35
Nov 2013	144	37	22
Dec 2013	53	26	26
Jan 2014	47	21	28
Feb 2014	97	36	50
Mar 2014	71	26	28
Apr 2014	78	38	40
May 2014	58	40	40
Jun 2014	79	25	35
Jul 2014	83	18	27
Aug 2014	52	31	46
Sep 2014	58	31	39
Oct 2014	91	24	42
Nov 2014	70	29	29
Dec 2014	33	27	24
Jan 2015	75	34	40
Feb 2015	64	30	46
Mar 2015	75	31	37
Apr 2015	56	25	31
May 2015	60	30	38
Jun 2015	98	47	61
Jul 2015	84	42	55
Aug 2015	55	30	39
Sep 2015	69	23	42
Oct 2015	77	22	36
Nov 2015	76	37	40
Dec 2015	61	22	26
Jan 2016	45	27	41
Feb 2016	74	30	38
Mar 2016	92	34	50
Apr 2016	58	33	45
May 2016	78	33	51
Jun 2016	82	27	44
Jul 2016	62	22	33
Aug 2016	66	33	36
Sep 2016	95	24	50
Oct 2016	121	19	28
Nov 2016	172	33	45
Dec 2016	74	27	39
Jan 2017	105	20	33
Feb 2017	130	34	53
Mar 2017	195	45	29
Apr 2017	117	48	52
May 2017	144	63	38
Jun 2017	132	68	44
Jul 2017	235	73	42
Aug 2017	244	69	42
Sep 2017	276	80	36
Oct 2017	290	51	39
Nov 2017	271	41	26
Dec 2017	189	48	33
Jan 2018	318	60	39
Feb 2018	296	64	50
Mar 2018	256	67	64
Apr 2018	290	63	40
May 2018	269	48	29
Jun 2018	155	35	27
Jul 2018	222	45	33
Aug 2018	222	32	38
Sep 2018	280	41	40
Oct 2018	278	41	34
Nov 2018	312	40	36
Dec 2018	202	24	21
Jan 2019	289	60	48
Feb 2019	269	45	55
Mar 2019	317	42	40
Apr 2019	257	57	38
May 2019	262	32	38
Jun 2019	194	43	33
Jul 2019	280	38	41
Aug 2019	263	58	50
Sep 2019	215	35	33
Oct 2019	268	51	42
Nov 2019	345	54	29
Dec 2019	291	47	40
Jan 2020	347	43	31
Feb 2020	294	65	39
Mar 2020	213	50	31
Apr 2020	319	29	30
May 2020	362	54	44
Jun 2020	309	42	38
Jul 2020	287	35	39
Aug 2020	247	38	31
Sep 2020	345	41	32
Oct 2020	286	50	25
Nov 2020	406	57	38
Dec 2020	451	58	52
Jan 2021	567	51	41
Feb 2021	516	62	51
Mar 2021	506	83	57
Apr 2021	445	62	51
May 2021	296	71	59
Jun 2021	67	65	59
Jul 2021	37	34	28
Aug 2021	65	57	28
Sep 2021	78	69	35
Oct 2021	603	74	26
Nov 2021	588	67	37
Dec 2021	795	66	32
Jan 2022	595	98	50
Feb 2022	715	97	42
Mar 2022	874	97	69
Apr 2022	887	93	59
May 2022	860	79	51
Jun 2022	855	95	51
Jul 2022	808	96	46
Aug 2022	881	74	42
Sep 2022	733	97	44
Oct 2022	774	72	36
Nov 2022	901	82	38
Dec 2022	647	55	27
Jan 2023	827	78	41
Feb 2023	631	66	34
Mar 2023	726	65	53
Apr 2023	549	52	40
May 2023	508	53	56
Jun 2023	724	54	46
Jul 2023	535	87	36
Aug 2023	852	65	40
Sep 2023	478	61	42
Oct 2023	741	56	24
Nov 2023	655	86	35
Dec 2023	936	78	38
Jan 2024	949	91	98
Feb 2024	922	47	48
Mar 2024	868	89	60
Apr 2024	609	75	23
May 2024	855	57	31
Jun 2024	430	43	15
Jul 2024	860	43	28
Aug 2024	394	33	12
Sep 2024	477	45	21
Total	48972	7835	6398

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