Objectives To prospectively investigate the prevalence of fat deposition in dilated cardiomyopathy (DCM) by fat-water separation imaging. An auxiliary aim was to determine the relationship between LV fat deposition and characteristic myocardial fibrosis, as well as cardiac functional parameters.
Methods Forty-eight patients with DCM were scanned on a 1.5 T MR scanner (MAGNETOM Avanto, Siemens, Germany) after written informed consent was obtained. The MR scan protocols included a series of short-axis LV cine imaging for functional analysis, fat-water separation imaging using VARPRO, and late gadolinium enhanced (LGE) imaging for fibrosis. Fat-water separation imaging was covered the entire LV myocardium. Fat deposition and fibrosis location were compared to the scar regions on LGE images using 17-segment model. Statistical comparisons of LV global functional parameters, fibrosis volumes, and fat deposition were carried out using the Pearson correlation, student t test and multiple regressions.
Results A fat deposition prevalence of 29.2% (14/48) was found in areas of DCM. The patients with fat deposition had larger myocardial fibrosis (27.0±15.1 cm3 vs 12.8±6.1 cm3; p<0.01), larger LVEDV (267.8±48.8 ml vs 201.6±46.5, p<0.01) and decreased LV ejection fraction (19.5%±8.4 vs 29.0%±12.1; p<0.01). The volume of fat deposition was correlated with scar volume, LV ejection fraction, LV end-diastolic volume index, and LV end-systolic volume index.
Conclusions Fat deposition is quite a common phenomenon in DCM. And it is associated with DCM characteristics such as fibrosis volume and LV function.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.