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Impaired endothelial function in persons with obstructive sleep apnoea: impact of obesity
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  • Published on:
    The significant association between apnoea-hypopnoea index and flow-mediated dilation of brachial artery: statistical consideration on its validity

    I read with interest the cross-sectional study by Namtvedt et al. (1) for 77 adults, who were sampled from 30,000 individuals aged 30-65 years. They concluded that there was a significant positive association between obstructive sleep apnoea (OSA) and endothelial dysfunction by using indicators of apnoea-hypopnoea index (AHI), flow-mediated dilatation (FMD), sex and some cardiovascular risk factors. Atkinson made a query...

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    Conflict of Interest:
    None declared.
  • Published on:
    Allometric scaling is useful for reliable comparisons of flow-mediated dilation

    One of the most consistent findings in research on percentage flow- mediated dilation (FMD%) is the negative correlation between baseline arterial diameter (Dbase) and FMD% itself. The study by Namtvedt et al.(1) is no exception in this respect. FMD% is obviously already an attempt to "normalise" the measured change in arterial diameter (in mm) for variability in Dbase, but seems to do this job poorly (2,3).

    In a...

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    Conflict of Interest:
    None declared.