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Funding This study was supported in part by Scientific Research Grants-in-Aid 20590837 and 23591041 from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to TN); a grant (AS 232Z01302F) from the Japan Science and Technology Agency (to TN); a grant from the Suzuken Memorial Foundation (to TN) and the Intramural Research Fund of National Cerebral and Cardiovascular Center (to NM).
Competing interests None.
Contributors TN mainly wrote the manuscript. YN, KK, and NM criticised it and provided the useful discussion.
KN and KK are supervisors and they provided useful comments to the manuscript.
Provenance and peer review Not commissioned; internally peer reviewed.
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