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Contributors All authors contributed to writing the manuscript.
Funding British Heart Foundation Chair (CH/09/002), Intermediate Fellowship (FS/10/024/28266) and Clinical Research Scholarship (SS/CH/09/002).
Competing interests NLM has received honoraria from Abbott Diagnostics and acted as a consultant for Beckman-Coultar and Abbott Diagnostics. All other authors have no competing interests or financial disclosures to declare.
Provenance and peer review Commissioned; internally peer reviewed.