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The Authors' reply We thank Dr Ammirati and his colleagues for their very valuable comments1 on our paper.2 We agree with their interpretation, the low incidence of non-fatal strokes in the medical arm (<1% per annum) makes it very difficult to demonstrate a significant reduction in events with any intervention. This is even more the case for invasive interventions which are of course associated with a periprocedural complication …
Contributors All authors contributed significantly to this text and have approved the final version. PM has drafted the text and the other authors have revised it critically for its intellectual content.
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.
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