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Correspondence
  1. Pascal Meier1,2,
  2. Mathias Wolfrum3,
  3. Georg M Froehlich1,
  4. Leanne K Casaubon,
  5. Alexandra J Lansky2
  1. 1 Yale—UCL Cardiovascular Research Program, The Heart Hospital, University College London Hospitals UCLH, London, UK
  2. 2 Division of Cardiology, Yale Medical School, New Haven, Connecticut, USA
  3. 3 Division of Internal Medicine, Spital Zollikerberg, Zollikerberg, Switzerland
  4. 4 Division of Neurology, Stroke Program, Toronto Western Hospital, Toronto, Canada
  1. Correspondence to Dr Pascal Meier, Yale—UCL Cardiovascular Research Program, The Heart Hospital, University College London Hospitals, UCLH16-18 Westmoreland Street, London W1G 8PH, UK; pascalmeier74{at}gmail.com
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http://dx.doi.org/10.1136/heartjnl-2013-304531

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    The Authors' reply We thank Dr Ammirati and his colleagues for their very valuable comments1 on our paper.2 We agree with their interpretation, the low incidence of non-fatal strokes in the medical arm (<1% per annum) makes it very difficult to demonstrate a significant reduction in events with any intervention. This is even more the case for invasive interventions which are of course associated with a periprocedural complication …

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    Footnotes

    • Contributors All authors contributed significantly to this text and have approved the final version. PM has drafted the text and the other authors have revised it critically for its intellectual content.

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.

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