Responses
Genetics of heart disease
Original article
The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism
Compose a Response to This Article
Other responses
Jump to comment:
- Published on: 23 November 2015
- Published on: 23 November 2015The possible impact of lack of ethnic and geographical diversity on the association of MTHFR mutations, homocysteine levels and heart disease outcomesShow More
Methylenetetrahydrofolate reductase (MTHFR) plays an important role in conversion of homocysteine to methionine by catalyzing the production of 5-methyl tetrahydrofolate hence effectively decreasing plasma homocysteine levels. The MTHFR 677C>T nonsynonymous single nucleotide polymorphism (SNP) leads to a substitution of Valine for Alanine and results in the formation of a thermolabile variant of the enzyme with decr...
Conflict of Interest:
None declared.