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Contributors Design by RPC. Literature review, drafts and revisions by RPC and NR. Final critical review and amendments by RPC.
Funding RPC and NR acknowledge the support of the BHF Centre of Research Excellence, Oxford. RPC is a Wellcome Trust senior research fellow in clinical science. Our laboratory is supported by the Oxford Comprehensive Biomedical Research Centre, NIHR funding scheme.
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.
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