Objective To establish the method- ultrasonic echocardiography (UCG) testing left ventricular ejection fraction (LVEF) of chick embryos to evaluate cardiodepressant autoantibodies in patients with dilated cardiomyopathy (DCM) and heart failure (HF).
Methods 36 cases with DCM patients with HF (DCM group) and 23 cases of coronary heart disease patients with HF (non-DCM group) were included. Cardiodepressant antibodies were determined by UCG of 18-day old chick embryos after adding the patients’ purified immunoglobulin G.
Results EF of non-DCM group is 81.03 ± 2.67%, and it of DCM group is 81.24 ± 2.33%. EF is 62.04 ± 2.98% in 23 cases of DCM group.
Conclusions Cardiodepressant antibodies were found in 63.9% of 36 patients with DCM and had no relation to other clinical parameters.