Objective To investigate the clinical application of serum cysteine protease inhibitor C (Cystatin C, Cys-C) determination in early renal impairment in essential hypertensive by comparing the differences of renal function indices in essential hypertensive with different glomerular filtration rate (GFR) levels.

Methods Two hundred and thirteen cases of essential hypertensive patients treated at the First Affiliated Hospital of Xinjiang Medical University from October 2011 to September 2012 were enrolled, there were one hundred and thirteen males and one hundred females, the average age of all the patients was (51.2 ± 12.7) years. the GFR was detected, all the patients were divided into three groups according to the GFR levels: renal moderate and severe impairment group (GFR < gfr90ml/min). To investigate the clinical application of Cys-C determination in early renal impairment in essential hypertensive by detecting the renal function indices (urea, creatinine, uric acid, Cys-C, 24 hours urine protein, microalbuminuria) related to the GFR. < /gfr.

Results Creatinine in renal moderate and severe impairment group was statistically higher than those in renal mild impairment group and normal renal function group (P < /span > <0.05), Cys-C in renal moderate and severe impairment group was statistically higher than those in renal mild impairment group and normal renal function group (P < /span > <0.05), Cys-C in renal mild impairment group was statistically higher than those in normal renal function group (P < /span > <0.05), the relationship of uric acid, 24 hours urine protein, urea, creatinine, microalbuminuria, Cys-C and GFR was negatively correlated, and the close degree was gradually increased, the close degree between Cys-C and GFR was the highest.

Conclusions Cys-C is one of the important diagnostic indexes in early renal impairment in essential hypertensive. It contributes to predicting the decline of renal function in the early stage.