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GW24-e0326 A diplotype of the CYP2C9 gene is associated with coronary heart disease in the Chinese Han population
  1. Fuzhenyan Zhuqing,
  2. Mayitong
  1. Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China


Objectives Cytochrome P450 (CYP) 2C9 is expressed in the vascular endothelium and metabolises arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which has a crucial role in the modulation of cardiovascular homeostasis. The aim of the present study was to assess the association between the human CYP2C9 gene and coronary artery disease (CAD) in a Han Population of China.

Methods A total of 301 CAD patients and 220 control subjects were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP2C9 gene (rs4086116, rs2475376, rs1057910, and rs1934967) by a Real -time PCR instrument. The data was assessed for 3 groups: total, men, and women via diplotype-based case–control studies.

Results For men, the distribution of the dominant model of SNP2 (rs2475376) (CC vs CT + TT) was slightly lower in CAD patients than in control participants (P = 0.045). For women, the distribution of genotypes, dominant model and alleles of SNP2 (rs2475376) showed significant difference between the CAD patients and control participants (P = 0.033, P = 0.010 and P = 0.038, respectively). The significant difference of the dominant model (CC vs CT + TT) was retained after adjustment for covariates in women, but not in men (for women, OR: 0.412, 95% confidence interval [CI]: 0.222-0.766, P <0.005; and for men, OR: 1.372, 95% CI: 0.861-2.186, P = 0.184). For men, the CCAC/CCAT diplotype were lower in the CAD patients than control participants (P = 0.024). For women, the two haplotype (C-T-A-C, C-C-A-T) and two diplotypes (CTAC/CTAC, CTAC/CCAC) in CYP2C9 gene showed significant difference between the CAD patients and control participants (P = 0.0032, P = 0.0016 and P = 0.004, P = 0.016 respectively).

Conclusions The results of this study indicate that, in Chinese men, the CCAC/CCAT diplotype of CYP2C9 may be a useful genetic marker of CAD; in women, CAD is associated with the rs2475376T allele of CYP2C9, in addition, CTAC/CTAC and CTAC/CCAC diplotypes could be a useful genetic marker of CAD.

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