Objectives Recently, the prognostic role of N-terminal pro-brain natriuretic peptide (NT-pro BNP) in heart failure and coronary diseases has been demonstrated in many studies. SYNTAX score was pioneered as an anatomical-based risk score that aided in this decision-making process in appropriately informing patients electing to undergo coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). However is not known if there is a relation between NT-pro BNP levels and SYNTAX score (SS). A present study came to investigate the relationship between plasma NT-pro BNP level and extent and complexity of coronary lesions assessed using SS in patients with stable angina pectoris candidate for coronary angiography.

Methods The study population included 203 consecutive patients with stable angina and intend for selective coronary angiography. SS was calculated in all participants, According to SS value,all subjects were divided into three groups: low risk (< 22), intermediate risk (23-32), and high risk (≥ 33).blood samples were drawn from femoral or radial artery for NT-pro BNP measurement just before the catheterisation of left coronary.

Results Regarding the role of N terminal pro BNP for assessing severity of coronary lesions based on SS, The NT pro BNP level increased significantly as risk classification of SS upgraded (P < 0.05). Linear regression analysis showed that plasma NT-pro BNP level was significantly associated with SS (r = 0.314, P < 0.01).

Conclusions NT-pro BNP can be a good parameter for predicting severity of coronary lesions. NT-pro BNP level was significantly associated with the extent and complexity of coronary artery disease.